Arizona (5-5, 4-3 Pac-12) has opened as a 10.5-point underdog for the Nov. 17 game against the Cougars (9-1, 6-1) in Pullman. That marks the third consecutive road game for the Wildcats in which they have been underdogs by 10 or more points.
Washington State, which leads the North Division by a game over Washington, needs a win to stay in the hunt for the College Football Playoff. Arizona is still alive for the South Division title but would need Utah (7-3, 5-3) to lose at Colorado on Saturday afternoon.
Arizona is 6-4 against the spread this season, 2-2 in road games. Wazzu is 9-1 ATS, the only game it failed to cover a 19-13 win over California in its last home game on Nov. 3.